acetaminophen liver glutathione depletion Frontiers Downregulation of Glutathione-Mediated Detoxification Capacity
Description
What has been lacking is an integrated and quantitative understanding of the kinetics of APAP metabolism, of how APAP dosage affects NAPQI synthesis and GSH concentrations in the liver, of how NAC stimulates the synthesis of GSH, and of how the dosage and timing of NAC affect detoxification of NAPQI

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J., Ghaffari, A
