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Since ROS-dependent DNA damage is markedly increased in myeloid cells after Bcr-Abl transformation 18 , we hypothesize that blocking dTTP and dCTP supply might exacerbate replication stress and DNA damage in Bcr-Abl-transformed cells, thereby jeopardizing cell survival
10.1089/neu.1996.13.223 J
Increasing evidence suggests that IGFs play a crucial role in the development of PCa, including in the process of epithelial-mesenchymal transition (Kawada et al., 2006)
16, S2S34
