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Administered at a dose of 360 mg/kg for 14 days, the extract markedly reduced IBA-1, IL-1, A1-42, and phosphorylated tau (p-tau) levels, highlighting its anti-inflammatory and neuroprotective properties (Wang Y

Unlike traditional anti-RA drugs, SI has been consumed as a traditional food in cooked and roasted form (Goyal et al., 2022), which has also drawn considerable interests from pharmacologists due to its anti-inflammatory properties (Thi Phuong Nhung et al., 2023), and its ability to regulate gut microbiota based inflammatory and immune diseases (Li et al., 2020b)

However, before iPSCs can advance to clinical trials, several issues need to be addressed, including the correction of mutations, induction of differentiation towards neuronal phenotypes, and ensuring the proliferation and long-term survival of iPSC-derived DA neurons following transplantation