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The participants were treated with standard therapies alone or with 150 mg Pycnogenol or 400 mg cranberry extract daily for 60 days

In a prospective study, high urinary betaine excretion was also associated with increased risk of heart failure in 325 subjects without diabetes mellitus who had been hospitalized for acute coronary syndrome (50)

Somigliana E, Sarais V, Reschini M, et al
