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Maintaining proper B12 levels is also important for a healthy metabolism, mood regulation, and clear cognitive function

Rare hypersensitivity reactions to B12 preparations can occur, which might include systemic symptoms, though joint pain specifically is not typically reported

Recognising Symptoms of B12 Deficiency Beyond Tiredness While persistent tiredness is often the presenting complaint, vitamin B12 deficiency produces a constellation of symptoms affecting multiple body systems

Leukemia 29:20392049 Richardson P, Perrot A, San-Miguel J, Beksac M, Spicka I, Leleu X et al (2021) Updates from ICARIA-MM, a phase 3 study of isatuximab (Isa) plus pomalidomide and low-dose dexamethasone (Pd) versus Pd in relapsed and refractory multiple myeloma (RRMM)