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10.1111/jgh.12751 101

Neuroendocrine Reset: It modulates the pineal gland, though the review notes a critical nuance: it may not directlystimulate melatonin secretion in all contexts but rather sensitizes pinealocytes or regulates the circadian machinery (e.g., Per1, Bmal1 genes)

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Clinically, SB has shown therapeutic potential primarily in ulcerative colitis, with more limited data in Crohns disease
