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doi: 10.1042/CS20180306 78 GillS
doi: 10.1136/thoraxjnl-2012-202432
These RNS, adding themselves to ROS, cause a further oxidation state, in this case nitro-oxidation, which can cause lipid peroxidation, DNA fragmentation, the nitration of proteins, and the alteration of vascular tone (vasoconstriction) [43,59]
This process involves specific chemical conditions that promote the binding of functional groups in the TSA molecule to sulfonate ions, resulting in the formation of TSA sulfonate sodium, which exhibits increased water solubility and enhanced bioactivity (221)
