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Catalytically active GGT is found in atherosclerotic plaques (90) and the GGT activity within the atherosclerotic plaques was found to correlate with systemic GGT activity (91) and histological indexes of plaque instability (92)

When R-spondin 2 was added to explant cultures from wildtype mice, the number of outer hair cells decreased modestly, further indicating that R-spondin 2 has the opposite effect of -catenin activation in the developing cochlea and do not appear to potentiate canonical Wnt signaling to increase the number of hair cells (Jacques et al., 2012

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