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Activation of these pro-inflammatory pathways alters insulin signaling, increasing insulin resistance, and contributing to metabolic dysfunction underlying diabetes onset (36, 37)

Crucitti T, Jespers V, Mulenga C, Khondowe S, Vandepitte J, Buv A
doi: 10.1016/s0014-2999(99)00200-9

MOTS-c acts at low concentrations to improve RPE cell viability and mitochondrial biogenesis and function [122]
