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they are not FDA-approved for general consumer use, retail sale or recreational selfadministration and are dispensed exclusively through licensed pharmacies to patients under active clinical care
10,11 EE, a synthetic estrogen and a key component of most combined oral contraceptives, has been shown to significantly influence oxidative stress mechanisms
However, IL-6 is often overlooked as also an anti-inflammatory cytokine, as IL-6 also dampens the inflammatory cascade by signaling for the release of various anti-inflammatory cytokines such as interleukin-10 (IL-10) [52]
