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Additionally, Nrf2 overactivation in hepatoma cells inhibits the pro-inflammatory response by suppressing cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, creating a favorable environment for malignant cell survival and protecting them from oxidative stress [138]
Biochim Bioph Acta 721:374384, 1982
6 AsimusS.ElsherbinyD.HaiT
Metformin primarily reduces hepatic gluconeogenesis, thereby lowering glucose output
