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performed the high-throughput screening based on the library of Bayer compounds, and found that 2-amino-3-cyano-4-aryl-6-(2-hydroxy-phenyl)pyridine analogue ( 68 , Figure 17 ) displayed a potent inhibitory activity against IKK (IC 50 = 1500 nM) [180]
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Another pathway of interest is the mitogen activated protein kinase (MAPK) cascade, which can be activated by H 2 O 2 and subsequently translocated into the nucleus to activate specific transcription factors (Lebrun-Garcia et al
they all developed characteristic changes on the blood film [see Fig 2
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