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This is particularly important in situations of increased oxidative damage, such as during intense physical exercise or exposure to environmental toxins

Pediatrics: No adverse effects were noted following IV infusion of acetylcysteine at a mean rate of 4.2 mg/kg per hour for 24 hours in 10 preterm infants (gestational age of 25-31 weeks and weight of 500-1380 g) or following infusion of acetylcysteine 0.1-1.3 mg/kg per hour for 6 days in 6 neonates (gestational age of 26-30 weeks and weight of 520-1335 g)

By analyzing the geometry, energetics, and prevalence of each interaction type, we highlight how structural information can guide rational lead optimization

Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) Biochem J