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In the 2020 review, Lymphoblastoid Cell Lines as Models to Study Mitochondrial Function in Neurological Disorder, Annesley and Fisher explained why theyve turned to cell lines to study mitochondrial functioning

However, it is worth noting that early-stage committed MSCs can also de-differentiate, depending on their local cellular microenvironment

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Hydrophobic or charged hydrophilic molecules diffuse poorly through mucus, while uncharged hydrophilic molecules can move quickly through the mucin mesh, with smaller molecules moving almost as fast as water