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The investigators attributed the angiogenic effect to upregulation of vascular endothelial growth factor receptor 2 (VEGFR2) and activation of the Aktendothelial nitric oxide synthase (eNOS) signaling pathway
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Their study in adult male mice indicated that HDCA targets intestinal farnesol X receptors and enhances the abundance of probiotic species in the gut, while activating hepatic CYP7B1 and PPAR through the enterohepatic axis (Fig
