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19 On the other hand, the receptor-mediated approach has gained attention as a potentially safe and effective method for enhancing brain-targeting capability without disrupting the BBB membrane
Sig Transduct Target Ther 5 , 280 (2020)

Dingding L, Yan Y

In support of this concept, knockdown of CaSR expression blocks the ability of high extracellular Ca 2+ concentrations ([Ca 2+ ] e ) to promote cell differentiation and matrix mineralization in cultured chondrocytes (46)
