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doi: 10.1074/jbc.272.16.10585

A Closer Look at B12 Injections for Mood Support As daylight hours shorten during fall and winter months, many people experience the combination of depressed mood, fatigue, and diminished interest in activities called seasonal affective disorder (SAD)

Nevertheless, personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN 2) represents an absolute contraindication to tirzepatide use
If you take both metformin and tirzepatide, your risk of B12 deficiency is compounded (no pun intended)