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[DOI] [PubMed] [Google Scholar] 2.Nriagu J
Circulation 2001
1999, pp
Upon agonist binding to TRL4, sphingomyelinase produces ceramide, which allows for interaction of the receptor with its co-activators myeloid differentiation factor-2 (MD-2) and CD14, resulting in subsequent activation of 3 parallel pathways: the p38-MAPK pathway, the PI3K/AKT pathway (cell survival/apoptosis), and the NFB pathway (proinflammatory cytokine release) (Rnnbck and Hansson, 1988
