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Introduction to Combination Therapy Modern metabolic strategies are moving toward combination approaches that address multiple biological systems simultaneously
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The increased ROS level stimulates the proliferation and survival of cancer cells through various signaling pathways, including MAPK/extracellularregulated kinase (ERK) pathway, phosphoinositide3kinase (PI3K)/AKT pathway, and protein kinase D (PKD)/NFB pathway [145]
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