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Immune checkpoint blockade (ICB) therapy can directly influence the metabolism of both immune cells and cancer cells, particularly through the upregulation of PD-1 expression (129)

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Immune-deficient NOD-SCID-IL2RG-/- mice (NSI mice, GIBH) were used as recipients for in vivo transplantation experiments

Its also advised to have several alcohol-free days each week to give your body time to recover
