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The drop in circulating leptin concentration is not exclusively caused by the change in adipose mass, as evidenced by the fact that the decline in plasma leptin was significantly larger than the change in adipose mass [123]

Thats why taking them together makes sense

doi: 10.1016/j.envpol.2023.123231 200 BouletJSridharVSBouabdallaouiNTardifJ-CWhiteM

It works through the red blood cells, by allowing them to carry oxygen more efficiently
