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A MnO(2) nanoparticle-dotted hydrogel promotes spinal cord repair via regulating reactive oxygen species microenvironment and synergizing with mesenchymal stem cells

The cellular redox state modulates SIRT1 activity, enabling antioxidants to act by key pathways ( SIRT1/FOXOs , SIRT1/NF-B , and SIRT1/p66Shc ) to protect CVD Further complexity arises from the regulatory crosstalk involving transcription factors (TFs) such as NF-B and sirtuins

Administering 0.5mL of this solution delivers 1mg total peptide, which for a 200g mouse equates to 5mg/kg

The obtained results were analyzed statistically and compared according to standard measurements