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Glutathione (GSH, PHR1359), glucose (G7528), glutamine (G8540), sodium pyruvate (S8636), 2-Deoxy-D-glucose (2-DG, D8375), trifluoromethoxy carbonyl cyanide phenylhydrazone (FCCP, C2920), and rotenone (R8875) were from Sigma-Aldrich (USA)

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Metabolite concentrations were normalized to the unsuppressed water signal, corrected for within-voxel CSF fraction, and expressed in Institutional Units

Electrostatic potentials for ScGrx6 and ScGrx7 were computed and mapped to the protein surface using the PoissonBoltzmann method of Swiss-PDB Viewer (dielectric constant solvent: 80, atomic partial charges, dielectric constant protein: 4, solvent ionic strength: 0.1 M)