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The successful transmission of neural signals from one cell to another in animals relies on the mutual conversion of chemical signals (neurotransmitters) and electrical signals, where ion fluxes are induced by neurotransmitters and the release of neurotransmitters is dependent on electrical signals 1,2,42

This increased SF penetration was not reduced in the free-ibuprofen and the non-targeted nanocarrier groups, only the 3-PLG-ibu-A-GSH treatment decreased the elevated permeability in a statistically significant way (Fig