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ROS can oxidatively modify regulatory subunits of the IB kinase (IKK) complex, promoting IB phosphorylation and subsequent degradation via the ubiquitin-proteasome pathway, thereby releasing active NF-B dimers (e.g., p50-p65) for nuclear translocation (S-Pessoa et al., 2023

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In vascular injury models, BPC-157 promotes healing of blood vessel damage and prevents pathological thrombus formation while supporting physiological hemostasis

doi: 10.3389/fimmu.2017.01448 18 BarbaroMOhlssonABorteSJonssonSZetterstromRHKingJet al
