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In this setting, TGF1 is probably the primary pro-fibrogenic factor in the formation of fibrotic plaques ( in vitro ( On the other hand, it is reported that TGF1 is a possible driver of Rho-associated coiled-coil protein kinase (ROCK) ( Fibrotic conditions often involve an imbalance between deposition and degradation of ECM in the proliferation and remodeling phase

These metabolic pathways were mutually affected and dynamically changed during drug dependence progression in MA self-administered rats, as shown in Fig

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doi: 10.1038/npp.1994.15
