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321 Meanwhile, significant microbial heterogeneity exists between multifocal tumor nodules in HCC, with specific bacterial communities enriched in metastatic clones, driving epithelial-mesenchymal transition and immune suppression

A.AlbelasiA.et al (2024)

Thus, Myc not only promotes metabolic changes via HIF1a stabilization but also establishes an immune-suppressive tumor microenvironment by enhancing M2 macrophage polarization and directly impairing CD8 T cell function

2003, titled The role of thiamine deficiency in alcoholic brain disease. When used in detox, thiamine helps protect neural tissue, supports mitochondrial function, and prevents irreversible brain injury