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Initiation of the ischemic cascade affects not only neuronal signaling but also several humoral mediators and diverse humoral pathways including opioids, NO, adenosine, bradykinin, catecholamines, heat-shock proteins, heme oxygenase, tumor necrosis factor-alpha (TNF- ), angiotensin, and prostaglandins (Vasdekis et al

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In addition, because Rhesus-related hemolytic disease of the newborn (HDN) is disappearing thanks to the implementation of appropriate prophylaxis, one can expect G6PD-related NNJ to be generally on the increase, at least in relative terms