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These include: MPs/NPs mediating mitochondrial dysfunction and energy metabolism disruption, leading to dopaminergic neuronal death 32,33

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The liver uses massive amounts of glutathione to break down ethanol and its toxic byproducts

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More help Handbook Version v2.0 Graphical Representation A graphical representation of the AOP.This graphic should list all KEs in sequence, including the MIE (if known) and AO, and the pair-wise relationships (links or KERs) between those KEs

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In the druggability evaluation, 12 proteins (CBR3, GSTO1, HHIP, IGF2R, MMP10, TLR2, CST3, FSTL5, GMPR2, IFI16, MAPK9, and NEO1) were predicted as druggable targets (Fig

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