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The importance of these findings relates to the fact that in the pre-initiation and/or early stages of colon carcinogenesis the disruption of cellular defence mechanisms (consisting of a battery of detoxifying or antioxidant enzymes) would make cells more susceptible to DNA damage by both unwanted by-products of normal cellular metabolism (Fig

[16] Waddington suggested visualising increasing irreversibility of cell type differentiation as ridges rising between the valleys where the marbles (analogous to cells) are travelling

The obtained data were processed by CONTIN fitting for intensity-weighted particle size distribution

Even drinking excessive tap water from Cu tube installation can increase the Cu burden
