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In some cases, especially for individuals with digestive issues or malabsorption conditions, the efficiency of oral supplementation can be severely compromised, leading to nutrient deficiencies despite adequate intake

In a study by Benkoucha et al., HGF exerted an anti-inflammatory effect through the generation of tolerogenic dendritic cells with the consequent suppression of auto-reactive T helper cells 1 (Th1) and Th17 cells and leading to the reduction of CD4 + T-cell-mediated nervous system injury in the experimental autoimmune encephalomyelitis (EAE) animal model of MS, in which HGF was overexpressed (HGF transgenic mice) (Benkhoucha et al., 2010)

Methods Sixtytwo women with melasma were enrolled and randomly assigned to two groups for 12 weeks of treatment

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