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Several phytochemicals, including berberine and other isoquinoline alkaloids, inhibit the assembly and activation of NLRP3, reducing mature pro-inflammatory cytokine release and mitigating neuroinflammation and neuronal loss in PD models ( Beyond immunomodulation, many plant phytoconstituents exert antioxidant and mitochondrial protective effects that are crucial in neurodegeneration

Given that mutations in epigenetic modifiers have become a marker of the ageing hematopoietic system, understanding the ageing-related clonal dominance mechanism of stem cells with mutations in epigenetic modifiers is of great interest

& Myers, M

Volume loss is a different problem requiring different interventions