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Description
Our novel NNMT inhibitors display excellent physical chemical properties (e.g., membrane permeability), selectivity, and cellular inhibitory activity against NNMT, concomitantly enhancing the levels of the cofactors SAM and NAD + that independently regulate cellular energy metabolism and epigenetic modifications
Digestive upset (oral/troche forms): Some compounded non-injectable versions may cause mild gastrointestinal discomfort
[1] Most often for at-home therapy, it will be IM injections
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
