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Administration of 0.5mL from 3 weeks of age (at tailing), would expect to give adequate concentrations up to 3-4 months

Methods Animals Animal experiments were performed with adherence to all national and local guidelines and regulations, the Guide for the Care and Use of Laboratory Animals 25 , and the ARRIVE guidelines, and with the approval of the Institutional Animal Care and Use Committee at The University of Texas Medical Branch (UTMB)

In addition, the treated mice showed cholesterol levels that were comparable to those of healthy mice

Specific Adverse Effects Reported in Clinical Trials While the overall safety profile was excellent, clinical trials documented all adverse events regardless of severity or causality