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As the next phase of this research, more sophisticated in vivo models, incorporating chronic injury paradigms, long-term follow-ups, and genetic or pharmacological modifications of inflammatory pathways, will be critical to substantiate the translational potential of this approach

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The regulation of IGF-1R-mediated signaling by IGFBPs in breast cancer, however, is complex, and the role of MMPs in this context has not yet been fully elucidated [122,123]

J.JurissonM
