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However, these methods have also a disadvantage associated with a difficulty of application thereof to industrial-scale production due to a low concentration of reactants and a prolonged reaction time of 2 to 3 days

Such conflicting results reported in low-quality studies are also biased because of various limitations in study designs, like a retrospective casecontrol design, prior undiagnosed medical conditions, medical history and time until the occurrence of the studied event, CRP measurement with various assays of different specificity/sensitivity/LoD scores/etc., different medication strategies, history of medications, relatively small study sample sizes, etc

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135 Although not considered a first-line treatment for obstructive sleep apnea, oral appliances are sometimes used in those who are unable to tolerate CPAP