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Livney, Y

Methylation Pathways & Chronic Fatigue: The Hidden Link Quick Answer Impaired methylation pathways, often linked to MTHFR gene polymorphisms (C677T and A1298C), may contribute to chronic fatigue, brain fog, and reduced stress tolerance
In previous studies, the connection between effort-based motivated performance in humans and levels of various metabolites in the accumbal region, was measured using 1 H-MRS at 7 Tesla before performing a physical effort-based motivated task (MIFT) (16, 17)

doi: 10.1016/j.clnesp.2017.09.006
