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These rules would then be applied to predictions from ACD/Labs and ChemAxon on a new data set to generate benchmark data to compare with the predictions of the three models developed in this work

145 ZhangY.YuanM.BradleyK

The cycle structure exists for a practical reason: continuous stimulation of the same receptor pathways can lead to reduced sensitivity over time, and a rest period allows the system to reset before the next cycle produces full effect
