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PMID: 22819472

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For institutional investors, this layered structure means that a biologics true LOE date is not the sequence patent expiry but rather the date by which a biosimilar can enter the market commercially without facing patent-infringement liability on any one of those layers or negotiate a settlement that grants a license

In part, the beneficial effect of selenium on genomic stability is associated with the antioxidation effect of selenoproteins such as GPXs and TXNRDs, which remove ROS before they cause DNA damage 134