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6.3 Oxidative stress and insulin resistance The Insulin Resistance (IR) explains the failure of muscles, fat, and liver to respond well to insulin and their incapacity to take up glucose from the blood

Likewise, the mRNA of inflammatory mediators (iNOS, IL-6, IFN and TNF-) are inhibited, with increased expression of HSP 70 and 90, and antioxidant proteins, such as HO-1, NQO-1, glutathione reductase, glutathione peroxidase 2 and GST-pi [19]

These results indicate the successful incorporation of the ruthenium catalyst into polymers that could self-assemble into well dispersed nanoparticles

FIGURE 1 Samples collection and storage To confirm APAP toxicity, 0.3 mL of blood were collected from the tail vein 4 hours after administering the APAP dose