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Recent studies have shown that SIRT1 exerts a neuroprotective effect in MPP+-treated dopaminergic neurons, primarily through deacetylation of PKM2, which improves brain lactate homeostasis and upregulates PGC-1 expression, promoting mitochondrial biogenesis in MPP+-treated cells 8,41
By blocking these receptors, magnesium helps to calm the hyper-reactive nervous system, reducing widespread muscle pain, cramping, and stiffness
