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For comparative analysis between groups, all samples (sampling 14) from controllers, were combined as we observed very low variation in CD38 expression and metabolic markers (exemplary shown for GLUT1, TMRM, and MTDR) over time per individual (Figure 6, B and C)

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Chronic BDNF treatment has been comparatively less investigated, besides it may represent a therapeutic option to obtain rescue of post-injury alterations of synaptic networks