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Human studies also provide evidence that GPx1 is protective against cardiovascular disease
Detailed biophysical studies (X-ray crystallography, EPR, NMR) elucidated that in GHK-Cu, the Cu(II) ion is coordinated by the imidazole side chain nitrogen of histidine, the alpha-amino nitrogen of glycine, and the deprotonated amide nitrogen of the glycine-histidine bond
Thus, ROS sources (NOX complexes, mitochondria, peroxisomes) and iron handling co-operate to define ferroptotic susceptibility (Zou et al
