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Chloramphenicol can interfere with blood response to B12 in some cases, and metformin or long-term acid reducers can contribute to low B12 status

This creates a regional pattern that does not resemble the results obtained with any other serotonergic drug using this method. Why This Matters This nigrostriatal focus is mechanistically intriguing because these regions are heavily involved in motor control, reward processing, and motivation

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They appear to be more likely in younger patients, but it's otherwise impossible to predict who will experience them