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Kaya, C
Icariin can also synergize with chemotherapy agents or immunotherapies to enhance efficacy and reduce toxicity
doi: 10.1007/s42729-020-00251-9 132 LiuM.XuJ.LouH.FanW.YangJ.ZhengS
The accumulation of intracellular ROS caused by low levels of tert-butyl hydroperoxide can induce the activation of p53 and lead to cell death, which can be specifically inhibited by the ferroptosis inhibitor Fer-1 but cannot be inhibited by other kinds of cell death pathway inhibitors, indicating that the form of death is ferroptosis
