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Additionally, many of the currently available clinical agents display the always on characteristic, where they illuminate disease sites through self-accumulation rather than being specifically activated by target molecules of interest, which leads to poor imaging contrast and compromised detection accuracy

Acta 411 , 14321436 (2010)

Immersion Syndrome : sudden death immediately following submersion in very cold water thought to be caused by vagal nerve stimulation resulting in overwhelming bradycardia

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