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Moreover, the placental macrophages of women with preeclampsia overexpress C5a, and their trophoblasts overexpress C5aR (413)

doi: 10.1016/S1369-5266(02)00289-3 185 SinghJ.KalamdhadA

doi: 10.3389/fphar.2014.00077

And because it is derived from a naturally occurring protein, its mechanism of action works with existing biological pathways rather than introducing foreign signaling
