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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Knezevic M., Gojkovic S., Krezic I., Zizek H., Vranes H., Malekinusic D., Vrdoljak B., Knezevic T., Horvat Pavlov K., Drmic D., et al

The newly determined cryo-EM structures in our work reveal that CCK and gastrin indeed adopt similar linear configurations perpendicular to the bilayer, penetrate into the receptor transmembrane domains (TMDs), and engage CCKR through extensive electrostatic and hydrophobic interactions with residues from all the extracellular loops (ECLs) and TM helices except TM5 (Fig