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This supposition is supported by the fact that co-application of kainate with histidine, a high affinity copper chelator, did not affect recovery of receptors from copper block, suggesting that direct copper binding may not be needed to exert its inhibitory effects (Weiser & Wienrich, 1996)
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Exercise-associated myokines such as irisin (Ciaowicz et al., 2025) and IL-6 (Mao et al., 2025) are linked to improved hepatic insulin sensitivity and mitochondrial performance, whereas catabolic signals released during sarcopenia, including myostatin, are associated with impaired hepatosteatosis and mitochondrial dysfunction (Joo and Kim, 2023)

In recent years, great progress has been made in engineered exosomes based on genetic modification
