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NICE has issued technology appraisals for semaglutide 2.4 mg (Wegovy) for weight management (TA875) and for tirzepatide (Mounjaro) for managing overweight and obesity , each with defined eligibility criteria

It should be emphasized that a review of clinical trials over the past 5 years shows that more and more attention is being paid to non-amyloid targets, including possible treatments of inflammation, protection of synapses and neurons, regulation of vascular factors, mitochondrial function and oxidative stress, lipid and glucose metabolism, circadian rhythm, and neurogenesis, as well as epigenetic interventions [40]